Atypical Presentation of Pediatric Systemic Lupus Erythematosus Complicated by Cryptococcal Meningitis

Cryptococcal meningitis in steroid-treated systemic lupus erythematosus.

A case of cryptococcal meningitis complicating steroidtreated systemic lupus erythematosus (SLE) which was successfully treated with amphotericin B is described. Although apparently rare, this mycotic infection has been reported from six patients with SLE in the medical literature over the past 10 years. Four of the six had been treated with steroids for periods ranging from 10 weeks to 6 years...

Concurrent presentation of cryptococcal meningoencephalitis and systemic lupus erythematosus

Cryptococcal meningitis is a recognized complication of systemic lupus erythematosus (SLE), with high mortality rates, particularly in those treated with immunosuppressive agents. We describe a patient diagnosed simultaneously with cryptococcal meningoencephalitis and SLE and reviewed four similar cases reported in the literature. In our case, profound low CD4 lymphocyte count and low complemen...

Initial presentation of systemic lupus erythematosus masquerading as bacterial meningitis.

Neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are well documented and recently reviewed. As many as 14% to 75% of patients with SLE eventually develop various degrees of neuropsychiatric manifestations. It is relatively rare, however, for patients with SLE to have such manifestations initially. According to a retrospective study of 140 patients with SLE, only 5 patients ...

Pediatric systemic lupus erythematosus

Cryptococcal meningitis as a complication of systemic lupus erythematosus treated with systemic corticosteroids.

Cryptococcosis, a disease of world-wide distribution, is uncommon in the British Isles where it usually presents as meningitis affecting patients with malignant disease of the reticulo-endothelial system, diabetes mellitus or those receiving systemic treatment with corticosteroids. The clinical features and physical signs of the disease are often non-specific and resemble those of tuberculous m...